|
KMID : 0374019920150030185
|
|
Ewha Medical Journal
1992 Volume.15 No. 3 p.185 ~ p.194
|
|
|
Passive and Active Immunization to Prevent Perinatal Verical Transmission in Infants Born to HBsAg Carrier Mothers
|
|
|
|
|
Abstract
|
|
|
Most of the perinatally infected infants from their HBsAg carrier mothers become chronic carrier and develop chronic liver disease. Prevention of vertical transmission is most important in elliminating hepatitis B virus infection. CDC recommended
passive and early active immunization in neonatal infants born to HBsAg carrier mothers to prevent perinatal vertical transmission.
The author checked anti-HBs titer at 7~9 month of age in 112 infants who were born to HBsAg carrier mother and were received HBIG 0.5cc at birth and 0.5cc Hepavax at 0.1. 6 month of age by CDC recommendation and studied the preventive effect of
passive
and early active immunization.
@ES The results were as follows:
@EN 1) Anti-HBs was positive in 98 infants(87.5%0 and negative in 14 infants(12.5%). Because 6 positive infants had anti-HBs below 10mIU/ml. only 92 infants(82.1%) had minimal protective anti-HBs.
2) Anti-HBs positive rate in infants of HBeAg(+) mothers was 77.8%(35/45) which was significantly lower than 94.0%(63/67) in infants of HBeAg(-) mothers(p<0.05).
3) Anti-HBs positive rate in infants of positive neonatal HBeAg was 77.8%(28/46) which was significantly lower than 92.1%(70/76) in infants of negative neonatal HBeAg(p<0.05).
4) Perinatal vertical transmission has occured in 2 infants of 14 anti-HBs(-) infants(14.3%). Among 8anti-HBs(-) infants of HBeAg(+) mothers. HBgAs was perinatally transmitted in 2 infants(25%). Six anti-HBs(-) infants of HBcAg(-) mothers were
not
infected.
5) Among 7 anti-HBs(-) infants with positive neonatal HBcAg2 infants(28.6%) was perinatally infected. Seven other anti-HBs(-) infants with negative neonatal HBeAg were not infected.
6) The maximum titer of 98 anti-HBs(+) infants by passive and early active immunization was as follows : 6 infants : <10mIU/ml. 8 infants : 11~100mIU/ml. 21 infants : 101~1000mIU/ml. 36 infants : 1001~10000mIU/ml. 28 infants : >10000mIU/ml The
anti-HBs
titer was below 1000mIU/ml in 35.9%(35/98) of anti-HBs(+) infants.
In conclusion. The preventive effect of passive and early active immunization was not complete especially in HBeAg(+) infants whose mothers had HBeAg.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|